![]() ![]() This study was funded by Valeant Pharmaceuticals North America LLC. T1 - Biafine topical emulsion accelerates excisional and burn wound healing in mice In conclusion, Biafine can be considered an alternative topical therapy for full-thickness excisional and burn wounds, owing to its advantageous biologically based wound healing properties.", Biafine application was associated with greater macrophage and lower neutrophil infiltration at earlier stages of healing when compared to other study groups. Biafine treatment accelerated wound closure clinically, with greater epidermal/dermal maturity, granulation tissue formation, and collagen quality and arrangement compared to other groups histologically. Biafine enhanced wound healing in murine full-thickness excisional and burn wounds compared to control, and surpassed Vaseline and SSD in respective wound types. Collagen deposition was measured and cell counts were performed. Wound tissue was excised and stained to appropriately visualize morphology, collagen, macrophages, and neutrophils. Daily treatments were administered and healing was measured over time. In the burn arm, mice were divided into untreated control, Biafine, and SSD groups. In the excisional arm, mice were divided into untreated control, Biafine, and Vaseline groups. Full-thickness excisional and burn wounds were created on two groups of 60 mice. The purpose of this study was to confirm this observation through gross and histologic assessments of wound healing using murine full-thickness excisional and burn wound models, and compare to common standards, Vaseline and silver sulfadiazine (SSD). It was previously suggested that the mechanism by which Biafine topical emulsion improves wound healing is via enhanced macrophage infiltration into the wound bed. In conclusion, Biafine can be considered an alternative topical therapy for full-thickness excisional and burn wounds, owing to its advantageous biologically based wound healing properties.Ībstract = "Macrophages play a fundamental role in wound healing therefore, employing a strategy that enhances macrophage recruitment would be ideal. ![]() It was previously suggested that the mechanism by which Biafine ® topical emulsion improves wound healing is via enhanced macrophage infiltration into the wound bed. Macrophages play a fundamental role in wound healing therefore, employing a strategy that enhances macrophage recruitment would be ideal.
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